Alteration of cystatin C in CSF of sciatica

with lumbar disk herniation; however, we do not yet fully understand its pathophysiological mechanism. Besides, the effect of the compression of the bulging disk directly on the nerve roots, biochemical, autoimmune effects, or both, of the nucleus pulposus on the nerve root may play an important role.1-4 As the cerebrospinal fluid (CSF) surrounds the spinal nerve roots, after injury to the roots there may be leakage of metabolites into the CSF as a result of the destruction of the blood-nerve S